1 Trebatická, et al. Treatment of ADHD with French maritime pine bark extract, Pycnogenol®. Eur Child Adolesc Psychiatry. 2006;15:329-335.

2. Dvoráková M, et al. The effect of polyphenolic extract from pine bark, Pycnogenol on the level of glutathione in children suffering from attention deficit hyperactivity disorder (ADHD). Redox Rep. 2006;11(4):163-72.

3. Dvoráková M, et al. Urinary catecholamines in children with attention deficit hyperactivity disorder (ADHD): modulation by a polyphenolic extract from pine bark (Pycnogenol®). Nutr Neurosci. 2007;10(3-4):151-157.

4. Weyns AS, et al. Clinical investigation of French maritime pine bark extract on attention-deficit hyperactivity disorder as compared to methylphenidate and placebo: Part 1: efficacy in a randomised trial. J Funct Foods. 2022;97:105246.

5. Weyns A-S, et al. Enhancing pediatric attention-deficit hyperactivity disorder treatment: exploring the gut microbiota effects of French maritime pine bark extract and methylphenidate intervention. Front. Nutr. 2024;11:1422253.

6. Elhossiny RM, et al. Assessment of probiotic strain Lactobacillus acidophilus LB supplementation as adjunctive management of attention-deficit hyperactivity disorder in children and adolescents: a randomized controlled clinical trial. BMC Psychiatry. 2023 Nov 9;23(1):823. doi: 10.1186/s12888-023-05324-4.

7. Hemamy M, et al. The effect of vitamin D and magnesium supplementation on the mental health status of attention-deficit hyperactive children: a randomized controlled trial. BMC Pediatr. 2021 May 12;21(1):230. doi: 10.1186/s12887-021-02683-3.

8. Ghoreishy, S.M, et al. Zinc status in attention-deficit/hyperactivity disorder: a systematic review and meta-analysis of observational studies. Sci Rep 11, 14612 (2021). https://doi.org/10.1038/s41598-021-94124-5

9. Hosoi M, et al. Pycnogenol® supplementation in minimal cognitive dysfunction. J Neurosurg 2018;62(3):279-284.

10. Verlaet AAJ, et al. Rationale for Dietary Antioxidant Treatment of ADHD. Nutrients. 2018;10(4):405. Doi:10.3390/nu10040405.

11. Belcaro G, et al. The COFU3 Study. Improvement in cognitive function, attention, mental performance with Pycnogenol® in healthy subjects (55-70) with high oxidative stress. Journal of Neurosurgical Sciences. 2015 Dec;59(4):437-446. PMID: 26635191.

12. Norris CM, et al. Pycnogenol protects CA3-CA1 synaptic function in a rat model of traumatic brain injury. Exp Neurol. 2016 Feb;276:5-12. doi: 10.1016/j.expneurol.2015.11.006. Epub 2015 Nov 29. PMID: 26607913; PMCID: PMC4715929.

13. Fan B, et al. Pycnogenol Attenuates the Release of Proinflammatory Cytokines and Expression of Perilipin 2 in Lipopolysaccharide-Stimulated Microglia in Part via Inhibition of NF-κB and AP-1 Activation. PLoS One. 2015 Sep 14;10(9):e0137837

14. Stough C, Pase MP. Improving Cognition in the Elderly With Nutritional Supplements. Curr Dir Psychol Sci. 2015;24(3):177-183. Doi:10.1177/0963721414567494

15. Belcaro G, et al. Pycnogenol® improves cognitive function, attention, mental performance and specific professional skills in healthy professionals aged 35–55. J Neurosurg 2014;58(4):239-24

16. Ryan J, et al. An examination of the effects of the antioxidant Pycnogenol on cognitive performance, serum lipid profile, endocrinological and oxidative stress biomarkers in an elderly J Psychopharmacol. 2008 Jul;22(5):553-62.

17. Chovanová Z, et al. Effect of polyphenolic extract, Pycnogenol, on the level of 8-oxoguanine in children suffering from attention deficit/hyperactivity Free Radic Res. 2006 Sep;40(9):1003-10.

19. Peng QL, et al. Pycnogenol® protects neurons from amyloid-peptide-induced apoptosis. Brain Res Mol Brain Res. 2002;104(1):55-65. Doi:10.1016/S0169-

20. Liu F, et al. Pycnogenol protects vascular endothelial cells from-amyloid-induced injury. Biol Pharm Bull. 2000;23(6):735-737. Doi:10.1248/bpb.23.735.

21. Liu F, Zhang Y, Lau BHS.Pycnogenol Improves Learning Impairment and Memory Deficit in Senescence-Accelerated Mice. Journal of Anti-Aging Medicine. 1999;2(4):349-355. Doi:10.1089/rej.1.1999.2.349

22. Heimann SW. Pycnogenol for ADHD? J Am Acad Child Adolesc Psychiatry. 1999;38(4):357-358. Doi:10.1097/00004583-199904000-0000.

23. Weichmann F, et al. Pycnogenol® French maritime pine bark extract in randomized, doubleblind,placebo-controlled human clinical studies. Front. Nutr. 11:1389374. doi: 10.3389/fnut.2024.1389374.