Referencias Medox

1. Escobar-Cervantes C et al. Anthocyanin-Rich Extracts from Bilberries and Blackcurrants in Human Health. J Clin Med. 2026;15:2083

2. Qin, Y, et al. Anthocyanin supplementation improves serum LDL- and HDL-cholesterol concentrations associated with the inhibition of cholesteryl ester transfer protein in dyslipidemic subjects. Am. J. Clin. Nutr. 2009, 90, 485–492

3. Zhu, Y, et al. Anti-inflammatory effect of purified dietary anthocyanin in adults with hypercholesterolemia: A randomized controlled trial. Nutr. Metab. Cardiovasc. Dis. 2013, 23, 843–849

4. Hassellund, S.S. et al. Effects of anthocyanins on cardiovascular risk factors and inflammation in pre-hypertensive men: A double-blind randomized placebo-controlled crossover study. J. Hum. Hypertens. 2013, 27, 100–106

5. Zhu, Y, et al. Anthocyanin supplementation improves HDL-associated paraoxonase 1 activity and enhances cholesterol efflux capacity in subjects with hypercholesterolemia. J. Clin. Endocrinol. Metab. 2014, 99, 561–569

6. Li, D, et al. Purified anthocyanin supplementation reduces dyslipidemia, enhances antioxidant capacity, and prevents insulin resistance in diabetic patients. J. Nutr. 2015, 145, 742–748.

7. Yang, L, et al. Role of Purified Anthocyanins in Improving Cardiometabolic Risk Factors in Chinese Men and Women with Prediabetes or Early Untreated Diabetes-A Randomized Controlled Trial. Nutrients 2017, 9, 1104.

8. Headley, L, et al. A Systematic Review andMeta-Analysis Investigating the Effects of a Bilberry and Blackcurrant Anthocyanin Extract (MEDOX®) on the Lipid Profile: Preliminary Results. In Poster; Evonik Industries: Darmstadt, Germany, 2019; 9. Xu, Z, et al. Anthocyanin supplementation at different doses improves cholesterol efflux capacity in subjects with dyslipidemia-a randomized controlled trial. Eur. J. Clin. Nutr. 2021, 75, 345–354

10. Tian, Z.; Li, K.; Fan, D.; Zhao, Y.; Gao, X.; Ma, X.; Xu, L.; Shi, Y.; Ya, F.; Zou, J.; et al. Dose-dependent effects of anthocyanin supplementation on platelet function in subjects with dyslipidemia: A randomized clinical trial. EBioMedicine 2021, 70, 103533

11. Aboonabi, A, et al. Anthocyanins reduce inflammation and improve glucose and lipid metabolism associated with inhibiting nuclear factor-kappaB activation and increasing PPAR-γ gene expression in metabolic syndrome subjects. Free Radic. Biol. Med. 2020, 150, 30–39.

12. Zhao, Y, et al. Dose-dependent reductions in plasma ceramides after anthocyanin supplementation are associated with improvements in plasma lipids and cholesterol efflux capacity in dyslipidemia: A randomized controlled trial. Clin. Nutr. 2021, 40, 1871–1878

13. Rodriguez-Mateos, A, et al. Circulating Anthocyanin Metabolites Mediate Vascular Benefits of Blueberries: Insights From Randomized Controlled Trials, Metabolomics, and Nutrigenomics. J. Gerontol. A Biol. Sci. Med. Sci.2019, 74, 967–976.

14. Thompson, K, et al. The effect of anthocyanin supplementation in modulating platelet function in sedentary population: A randomised, double-blind, placebo-controlled, cross-over trial. Br. J. Nutr. 2017, 118, 368–374

15. Thompson, K, et al. Anthocyanin supplementation in alleviating thrombogenesis in overweight and obese population: A randomized, double-blind, placebo-controlled study. J. Funct. Foods 2017, 32, 131–138

16. Aboonabi, A, et al. Anthocyanins in berries exhibited anti-atherogenicity and antiplatelet activities in a metabolic syndrome population. Nutr. Res. 2020, 76, 82–93

17. Gaiz, A, et al. Colson, N.; Shibeeb, S.; Singh, I. Anthocyanin Supplementation Alleviates Antithrombotic Risk by Inhibiting Platelet Activity in Humans. Altern. Ther. Health Med. 2022, 28, 44–49

18. Muscara, C, et al. Anthocyanins ameliorate palmitate-induced inflammation and insulin resistance in 3T3-L1 adipocytes. Phytother. Res. 2019, 33, 1888–1897

19. Yang, L, et al. Anthocyanins increase serum adiponectin in newly diagnosed diabetes but not in prediabetes: A randomized controlled trial. Nutr. Metab. 2020, 17, 78

20. Yang, L, et al. Effect of Anthocyanins Supplementation on Serum IGFBP-4 Fragments and Glycemic Control in Patients with Fasting Hyperglycemia: A Randomized Controlled Trial. Diabetes Metab. Syndr. Obes. 2020, 13, 3395–3404

21. Yang, L, et al. Anthocyanins regulate serum adipsin and visfatin in patients with prediabetes or newly diagnosed diabetes: A randomized controlled trial. Eur. J. Nutr. 2021, 60, 1935–1944

22. Yu L, et al. Remission of impaired glucose tolerance by anthocyanin supplementation: a randomized, double-blind, and placebo-controlled trial. Am J Clin Nutr. 2026;123(3):101210. Cimino, F, et al. Anthocyanins protect human endothelial cells from mild hyperoxia damage through modulation of Nrf2 pathway. Genes Nutr. 2013, 8, 391–399

23. Zhang, H, et al. Anthocyanin supplementation improves anti-oxidative and anti-inflammatory capacity in a dose-response manner in subjects with dyslipidemia. Redox Biol. 2020, 32, 101474

24. Aboonabi, A, et al. Cytoprotective effects of berry anthocyanins against induced oxidative stress and inflammation in primary human diabetic aortic endothelial cells. Chem. Biol. Interact. 2020, 317, 108940

25. Guo, Y, et al. A dose-response evaluation of purified anthocyanins on inflammatory and oxidative biomarkers and metabolic risk factors in healthy young adults: A randomized controlled trial. Nutrition 2020, 74, 110745

26. Parrado-Fernandez, C, et al. Anthocyanins attenuate lipid peroxidation and mitochondrial dysfunction generated by APPswe mutation or by chemical inhibition of mitochondrial complex I. Poster presented at: 13th International Conference on Alzheimer’s and Parkinson’s Diseases and Related Neurological Disorders (AD/PD™ 2017), Vienna, Austria, 29 March–2 April 2017

27. Karlsen, A, et al. Anthocyanins inhibit nuclear factor-kappaB activation in monocytes and reduce plasma concentrations of pro-inflammatory mediators in healthy adults. J. Nutr. 2007, 137, 1951–1954

28. Park, S.J, et al. Anthocyanins inhibit airway inflammation and hyperresponsiveness in a murine asthma model. Food Chem. Toxicol. 2007, 45, 1459–1467

29. Vugic, L, et al. Anthocyanin supplementation inhibits secretion of pro-inflammatory cytokines in overweight and obese individuals. J. Funct. Foods 2019, 64, 103596

30. Tang, X, et al. Purified anthocyanins from bilberry and black currant attenuate hepatic mitochondrial dysfunction and steatohepatitis in mice with methionine and choline deficiency. J. Agric. Food Chem. 2015, 63, 552–561

31. Bergland, A.K, et al. Effects of Anthocyanin Supplementation on Serum Lipids, Glucose, Markers of Inflammation and Cognition in Adults With Increased Risk of Dementia—A Pilot Study. Front. Genet. 2019, 10, 536

32. Zhang, P.W, et al. A CONSORT-compliant, randomized, double-blind, placebo-controlled pilot trial of purified anthocyanin in patients with nonalcoholic fatty liver disease. Medicine 2015, 94, e758

33. Cristani, M, et al. Protective activity of an anthocyanin-rich extract from bilberries and blackcurrants on acute acetaminophen-induced hepatotoxicity in rats. Nat. Prod. Res. 2016, 30, 2845–2849

34. Parrado-Fernandez, C, et al. Anthocyanins protect from complex I inhibition and APPswe mutation through modulation of the mitochondrial fission/fusion pathways. Biochim. Biophys. Acta 2016, 1862, 2110–2118